The NITRC Computational Environment (NITRC-CE) is a virtual computing platform pre-configured with many neuroimaging data analysis applications. Use NITRC-CE Classic instead of NITRC-CE LITE when you use many system-installed software packages to save time loading and maintaining versioning including: 3D Slicer, AFNI, ANTS, BrainSuite, CONN, Connectome Workbench, Connectome Viewer, C-PAC, DataLad, Docker, DTIPrep, FreeSurfer, FSL, gradunwarp, HCP Pipelines, HeuDiConv, LONI Pipeline Environment, MaCH, MRIcron, MRtrix, NeuroDocker, NEURON, PLINK!, Pydicom, DIPY, NiBabel, NIPY, NiPype, Singularity, SOLAR-Eclipse, SPM, and TrackVis. Leveraging NeuroDebian, NITRC-CE joins the family of successful NITRC services starting with the flagship, NITRC-Resources, the "go to" place for neuroimaging tools and resources. This Human Connectome Project (HCP) release of NITRC-CE includes software specific to connectome analysis and supports direct mounting of the HCP data on S3.