reference deployment

Biotech Blueprint on AWS

Cloud-based infrastructure for informatics software

This solution deploys Biotech Blueprint to the Amazon Web Services (AWS) Cloud. Biotech Blueprint is a reference architecture for scientific applications and is for biotechnology companies that want to manage their software on the cloud.

The core architecture provides the infrastructure for launching biotechnology applications directly from the AWS Service Catalog. This deployment creates the underlying infrastructure, according to AWS best practices, and configures it for identity management, access control, VPN, logging, alarms, and compliance auditing. It contains three partitioned virtual private clouds (VPCs) for production, development, and management processes.

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This solution was developed by AWS.

  •  What you'll build
  • This solution sets up the following:

    • A highly available architecture with three VPCs, each with two Availability Zones. The VPCs contain public and private subnets, according to AWS best practices, to provide you with your own virtual networks on AWS.
      • A production VPC into which you can deploy optional research and informatics software from the AWS Service Catalog.
      • A management VPC with AWS Client VPN endpoints in the public subnets. 
      • A development VPC to build and test research workloads.
    • Peering connections to allow Secure Shell (SSH) and remote desktop access from the management VPC to private subnets in the production and development VPCs.
    • AWS Config to assess, audit, and evaluate security compliance of your AWS resources and remediate deviations from the following conformance packs:
      • Operational best practices for HIPAA security
      • Operational best practices for AWS Identity and Access Management (IAM)
      • Operational best practices for Amazon S3
      • Operational best practices for NIST Cyber Security Framework (CSF)
      • AWS Control Tower Detective Guardrails
    • Amazon Route 53 for a private Domain Name System (DNS).
    • (Optional) An AWS Service Catalog portfolio with informatics software and computational biology tooling you can deploy into the production and development VPCs. For more information, refer to the Add-on products tab.
  •  How to deploy
  • To deploy Biotech Blueprint, follow the instructions in the deployment guide. The deployment process takes about 10 minutes and includes these steps:

    1. Sign in to your AWS account. If you don't have an AWS account, sign up at
    2. Launch the solution. You can choose from the following options:
      • Deploy using AWS CloudFormation. Deploy Biotech Blueprint using the AWS CloudFormation console. Use this option if you are unfamiliar with AWS CDK. Choose the AWS Region from the top toolbar before creating the stack.
      • Deploy using AWS CDK. Deploy Biotech Blueprint using AWS CDK. This option takes an additional 5 minutes to deploy. By using this option, you can enable a feature that restricts IAM actions to specific AWS Regions. For more information, refer to AWS CDK deployment in the deployment guide.
    3. Test the deployment.

    Amazon may share user-deployment information with the AWS Partner that collaborated with AWS on this solution.  

  •  Costs and licenses
  • You are responsible for the cost of the AWS services and any third-party licenses used while running this solution. There is no additional cost for using the solution.

    This solution includes configuration parameters that you can customize. Some of these settings, such as instance type, affect the cost of deployment. For cost estimates, refer to the pricing pages for each AWS service you use. Prices are subject to change.

    Tip: After you deploy a solution, create AWS Cost and Usage Reports to track associated costs. These reports deliver billing metrics to an Amazon Simple Storage Service (Amazon S3) bucket in your account. They provide cost estimates based on usage throughout each month and aggregate the data at the end of the month. For more information, refer to What are AWS Cost and Usage Reports?
  •  Add-on products
  • After deploying this solution, you can launch various informatics and scientific applications that are listed in the AWS Service Catalog. Launch each application either through this landing page or through their respective deployment guides. For more information, navigate to the links in the following table:

    Category Partner Product
    To install
    Compound registry ChemAxon Compound Registration Launch solution template
    Genomics analysis  Hail  Hail 0.2 Solution page | View guide
    Knowledge management Dotmatics Dotmatics suite Solution page | View guide
    Sample management Titian Mosaic FreezerManagement Solution page | View guide