This AWS re:Invent 2023 session explores best practices for creating multi-Region architectures on AWS. Presenters Joe Chapman and Neeraj Kumar discuss two customer scenarios to illustrate key concepts and challenges. They cover topics such as disaster recovery strategies, data replication, observability, and regional independence. The session emphasizes the importance of understanding business requirements, implementing proper fault isolation, and regularly testing recovery procedures. Key AWS services mentioned include Route 53 Application Recovery Controller, CloudFormation, and DynamoDB Global Tables. The presenters stress that multi-region architectures should be driven by specific business needs and carefully weighed against increased complexity and cost.