AWS HPC Blog
Author: Stefan Dittforth
Stefan Dittforth is a Senior Prototype Developer on the AWS Industries Prototyping and Customer Engineering team. He has developed AI-powered enterprise prototypes spanning generative diffusion models for drug discovery, autonomous DevOps agents, LLM-based map routing systems, and developer experience platforms.
Benchmarking the Oxford Nanopore Technologies basecallers on AWS
Oxford Nanopore sequencers enables direct, real-time analysis of long DNA or RNA fragments. They work by monitoring changes to an electrical current as nucleic acids are passed through a protein nanopore. The resulting signal is decoded to provide the specific DNA or RNA sequence by virtue of compute-intensive algorithms called basecallers. This blog post presents the benchmarking results for two of those Oxford Nanopore basecallers — Guppy and Dorado — on AWS. This benchmarking project was conducted in collaboration between G42 Healthcare, Oxford Nanopore Technologies and AWS.