Tag: DRAGEN

AstraZeneca’s genomic research requires extensive computational resources to analyze DNA sequences for developing life-saving therapies. As cloud infrastructure evolves with more powerful capabilities, customers can adopt them to see performance and efficiency gains. AstraZeneca successfully migrated to Amazon EC2 F2 instances for genomics, boosting performance by 60% and slashing costs by 70%.

In this blog, we provide a walkthrough of running Illumina DRAGEN v4.0 genomic analysis pipelines on AWS, showing accuracy and efficiency, copy number analysis, structural variants, SMN callers, repeat expansion detection, and pharmacogenomics insights for complex genes. We also highlight some benchmarking results for runtime, cost, and concordance from the Illumina DRAGEN DNA sequencing pipeline.