reference deployment

NVIDIA Clara Parabricks on AWS

Efficiently analyze large-scale genomic data

This Quick Start deploys NVIDIA Clara Parabricks, an accelerated genomics analysis framework, on the AWS Cloud. It helps researchers, clinical teams, and medical centers adopt Parabricks and run multiple standalone tools and pipelines for secondary and tertiary analysis of large-scale genomic data. You can analyze data for cancer sequencing projects, population studies, ribonucleic acid sequencing (RNA-seq), and more.  

The Quick Start builds an AWS environment that spans two Availability Zones for high availability, and provisions an AWS Batch compute environment for on-demand instances. The Quick Start environment includes Parabricks G4dn instances with graphics processing units (GPUs) for hardware acceleration.

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This Quick Start was developed by NVIDIA in collaboration with AWS. NVIDIA is an AWS Partner.

  •  What you'll build
  •  How to deploy
  •  Cost and licenses
  •  What you'll build
  • This Quick Start sets up the following:

    • A highly available architecture that spans two Availability Zones.* 
    • A VPC configured with public and private subnets, according to AWS best practices, to provide you with your own virtual network on AWS.*
    • In the public subnets:
      • Managed network address translation (NAT) gateways to allow outbound internet access for resources in the private subnets.*
      • A Linux bastion host in an Auto Scaling group to allow inbound Secure Shell (SSH) access to Amazon Elastic Compute Cloud (Amazon EC2) instances in public and private subnets.*
    • In the private subnets:
      • Parabricks deployed to Amazon EC2 instances.
      • An AWS Batch compute environment, job queue, and job definition for Parabricks instances.
    • An Amazon Elastic Container Registry (Amazon ECR) wrapper container for Parabricks.

    *  The template that deploys the Quick Start into an existing VPC skips the components marked by asterisks and prompts you for your existing VPC configuration.

  •  How to deploy
  • To deploy this Quick Start, follow the steps in the deployment guide, which includes these steps. The stack takes about 15 minutes to launch.

    1. Install Parabricks and perform predeployment steps. 
    2. Launch the Quick Start. Before you create the stack, choose the AWS Region from the top toolbar. You can choose from the following options.

    Amazon may share user-deployment information with the AWS Partner that collaborated with AWS on the Quick Start.  

  •  Cost and licenses
  • You are responsible for the cost of the AWS services and any third-party licenses used while running this Quick Start reference deployment. There is no additional cost for using the Quick Start.

    The AWS CloudFormation templates for Quick Starts include configuration parameters that you can customize. Some of the settings, such as the instance type, affect the cost of deployment. For cost estimates, see the pricing pages for each AWS service you use. Prices are subject to change.

    Tip: After you deploy the Quick Start, create AWS Cost and Usage Reports to track costs associated with the Quick Start. These reports deliver billing metrics to an Amazon Simple Storage Service (Amazon S3) bucket in your account. They provide cost estimates based on usage throughout each month and aggregate the data at the end of the month. For more information about the report, refer to What are AWS Cost and Usage Reports?