Amazon EC2 P6e-GB300 UltraServers accelerated by NVIDIA GB300 NVL72 are now generally available

Posted on: Dec 2, 2025

Today, AWS announces the general availability of Amazon Elastic Compute Cloud (Amazon EC2) P6e-GB300 UltraServers. P6e-GB300 UltraServers, accelerated by NVIDIA GB300 NVL72, provide 1.5x GPU memory and 1.5x FP4 compute (without sparsity) compared to P6e-GB200. 

Customers can optimize performance for the most powerful models in production with P6e-GB300 for applications that require higher context and implement emerging inference techniques like reasoning and Agentic AI.

To get started with P6e-GB300 UltraServers, please contact your AWS sales representative.

To learn more about P6e UltraServers and instances, visit Amazon EC2 P6 instances.