AWS HPC Blog

Category: Compute

A Technical Deep Dive into Amazon EC2 Hpc8a Performance for Engineering and Scientific Workloads

High performance computing (HPC) workloads continue to grow in scale and complexity. Whether simulating airflow over an aircraft wing, modeling structural behavior under load, or performing crash simulation and multi-physics analysis, these workloads demand sustained compute throughput, high memory bandwidth, and efficient scaling across large clusters. Improvements in any one of these dimensions can reduce […]

Scaling life sciences research by deploying AWS ParallelCluster and AWS DataSync

In life sciences research, managing large-scale computational resources and data efficiently is important for success. However, traditional on-premises environments often struggle to meet these requirements effectively. This post demonstrates how JSR Corporation transformed their research infrastructure using AWS ParallelCluster and AWS DataSync, achieving a 33% reduction in CPU usage and 85% in storage requirements. JSR’s […]

Evaluating next‑generation cloud compute for large‑scale genomic processing

AstraZeneca’s genomic research requires extensive computational resources to analyze DNA sequences for developing life-saving therapies. As cloud infrastructure evolves with more powerful capabilities, customers can adopt them to see performance and efficiency gains. AstraZeneca successfully migrated to Amazon EC2 F2 instances for genomics, boosting performance by 60% and slashing costs by 70%.

Optimize Nextflow Workflows on AWS Batch with Mountpoint for Amazon S3

Are you running genomic workflows with Nextflow on AWS Batch and experiencing bottlenecks when staging large reference files? In this post, we will show you how to optimize your workflow performance by leveraging Mountpoint for Amazon S3 to stream reference data directly into your Nextflow processes, eliminating the need to stage large static files repeatedly.

How Rivian modernized engineering simulation using AWS

This post was contributed by Ameya Kamerkar (Rivian), Vikram Pendyam (Rivian), Abhishek Chauhan (Rivian), Ajay Paknikar (AWS), Sandeep Sovani (AWS) Figure 1. Rivian’s custom Amazon Electric Delivery Vehicle (EDV) (Credits: Rivian media kit) In this post, we share how Rivian, a leading electric vehicle manufacturer, revolutionized their engineering simulation capabilities by migrating to AWS and […]

Running NVIDIA Cosmos world foundation models on AWS

Running NVIDIA Cosmos world foundation models on AWS provides powerful physical AI capabilities at scale. This blog covers two production-ready architectures, each optimized for different organizational needs and constraints.

How Daiichi Sankyo modernized drug discovery using AWS Parallel Computing Service

This blog was co-authored by Takehiro Nakajima and Mark Azadpour from AWS and Rintaro Yamada, Rei Kajitani and Ryo Kunimoto from Daiichi Sankyo In recent years, the informatics field of drug discovery has seen a rapid increase in workloads requiring large-scale parallel computing, such as genome analysis, structure prediction, and drug design. Daiichi Sankyo has […]

AWS at SC25 - Meet the Advanced Computing team at Booth #2207

Meet the Advanced Computing team of AWS at SC25 in St. Louis

We want to empower every scientist and engineer to solve hard problems by giving them access to the compute and analytical tools they need, when they need them. Cloud HPC can be a real human progress catalyst. If you run large scale simulations, tune complex models, or support researchers who consistently need more compute, the […]

AWS re:Invent 2025: Your Complete Guide to High Performance Computing Sessions

AWS re:Invent 2025 returns to Las Vegas, Nevada on December 1, uniting AWS builders, customers, partners, and IT professionals from across the globe. This year’s event offers you exclusive access to compelling customer stories and insights from AWS leadership as they tackle today’s most critical challenges in high-performance computing, from accelerating scientific discovery to optimizing […]