Sold by: Bioptimus
Deployed on AWS
The leading foundation model for computational pathology. H-optimus-1 turns H&E whole-slide images into task-agnostic embeddings for biomarker discovery, mutation prediction, and survival modeling, with state-of-the-art performance on 13 downstream tasks. 1.1B-parameter Vision Transformer pre-trained on 1M+ slides from 800,000+ patients across 50+ organ systems.
Overview
Use H-optimus-1 to build pathology models from H&E whole-slide images. Generate task-agnostic embeddings that preserve cellular and tissue-level context, then plug them into classifiers, survival models, or downstream heads for biomarker discovery, mutation prediction, patient stratification, tissue classification, cell counting, typing, and segmentation. Zero-shot and few-shot adaptation lets you fit a new task with linear probing or light fine-tuning instead of a full training run.
H-optimus-1 is a 1.1B-parameter Vision Transformer pre-trained on over 1 million H&E slides from more than 800,000 patients across 4,000+ clinical centers and 50+ organ systems (healthy and diseased tissues). On internal and public benchmarks, it delivers state-of-the-art performance across 13 downstream tasks on 15 datasets, including the public HEST benchmark.
Deploy H-optimus-1 as an Amazon SageMaker model package inside your AWS account. Run real-time inference via SageMaker endpoints or batch inference on S3. Whole-slide images stay in your VPC.
Highlights
- H-optimus-1 delivers state-of-the-art performance across 13 downstream tasks on 15 public and private datasets, including the public HEST benchmark; supports zero-shot and few-shot adaptation via linear probing or light fine-tuning with minimal task-specific training.
- H-optimus-1 is pre-trained on a proprietary cohort of billions of image patches sampled from over 1 million H&E slides representing more than 800,000 patients across 4,000+ clinical centers and 50+ organ systems, spanning healthy and diseased tissues.
- H-optimus-1 is a 1.1B-parameter Vision Transformer for H&E whole-slide images pre-trained with self-supervised learning at 0.5 MPP and 224x224 px tile resolution, producing 1,536-d task-agnostic embeddings that preserve cellular and tissue-level context.
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Pricing
Pricing is based on actual usage, with charges varying according to how much you consume. Subscriptions have no end date and may be canceled any time.
Additional AWS infrastructure costs may apply. Use the AWS Pricing Calculator to estimate your infrastructure costs.
Dimension | Description | Cost |
|---|---|---|
ml.g5.xlarge Inference (Batch) Recommended | Model inference on the ml.g5.xlarge instance type, batch mode | $540.00/host/hour |
ml.p3.2xlarge Inference (Batch) | Model inference on the ml.p3.2xlarge instance type, batch mode | $540.00/host/hour |
inference.count.m.i.c Inference Pricing | inference.count.m.i.c Inference Pricing | $0.001/request |
ml.g5.2xlarge Inference (Batch) | Model inference on the ml.g5.2xlarge instance type, batch mode | $540.00/host/hour |
Dimensions summary
H-Optimus-1 bills on usage, so you pay only for what you run. Two dimensions charge by host-hour, tied to the compute instance you pick for batch inference. One uses the ml.p3.2xlarge instance; the other uses the ml.g5.xlarge instance. Your cost scales with how long each instance runs. A third dimension charges per inference request, letting you pay by the number of requests processed instead of by time. You can choose the host-hour model for sustained batch jobs or the request-based model for per-call usage. These dimensions run as managed endpoints through Amazon SageMaker.
Top-of-mind questions for buyers
A host-hour is one hour that your chosen compute instance runs batch inference. You pay for each hour the instance stays active. The ml.p3.2xlarge and ml.g5.xlarge differ in their underlying hardware, so you select the instance type that fits your batch workload and compute needs.
The host-hour dimensions meter how long an instance runs, so a long batch job accrues more hours. The request dimension meters the number of inference requests processed, regardless of time. Choose host-hours for sustained batch runs and the request model when you want cost tied to call volume.
The host-hour dimensions meter running time, so a fully stopped instance accrues no software host-hour charges. The request dimension charges only per inference request processed. Underlying AWS infrastructure fees may still apply separately. These models run as managed endpoints through Amazon SageMaker.
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Delivery details
Amazon SageMaker model
An Amazon SageMaker model package is a pre-trained machine learning model ready to use without additional training. Use the model package to create a model on Amazon SageMaker for real-time inference or batch processing. Amazon SageMaker is a fully managed platform for building, training, and deploying machine learning models at scale.
Deploy the model on Amazon SageMaker AI using the following options:
Version release notes
v2.3.0 - Combined mode returns a tile embedding and its downstream output in a single forward pass. - Anonymized diagnostics endpoint (/diagnostics) and support bundles for reporting issues without sharing slide data. - Endpoint verification against the model's declared output contract, with typed error codes and remediation hints. - Coordinate-driven tile extraction (explicit tile list instead of a mask). Reliability - Slide-edge reads clamped to slide bounds; cuCIM and OpenSlide paths unified. - Server reports a terminal unhealthy state when all models fail to load. - Per-tile failures are isolated instead of aborting the whole slide. Compatibility - H-optimus-1 embeddings (1536-dim) and tissue segmentation unchanged. - Recommended instance: ml.g5.xlarge.
Additional details
Inputs
- Summary
H-optimus is a Foundation Model which accepts 224x224 pixel images at 0.5 MPP resolution and outputs an embedding feature vector of dimension 1536. The model accepts a single JSON object per request
- Limitations for input type
- Please note the input resolution should be 0.5 MPP (microns-per-pixel). Lower resolutions work less well
- Input MIME type
- application/json
https://github.com/bioptimus/h1-jumpstart/tree/main/data/input/real-time
https://github.com/bioptimus/h1-jumpstart/tree/main/data/input/batch
Input data descriptions
The following table describes supported input data fields for real-time inference and batch transform.
Field name | Description | Constraints | Required |
|---|---|---|---|
model_name | Selects the model to run. Must be "h1".
| String | Yes |
mode | Inference mode. Must be "embedding".
| String | Yes |
image_data | Base64-encoded PNG of a 224×224 RGB tissue tile extracted at 0.5 µm/px (MPP).
| String (base64)
| Yes |
slide_name | Identifier for the source whole-slide image.
| String | Yes |
x | Left edge of the tile within the source slide, in pixels.
| integer ≥ 0
| Yes |
y | Top edge of the tile within the source slide, in pixels.
| integer ≥ 0
| Yes |
width | Tile width in pixels. Must be 224.
| integer = 224
| Yes |
height | Tile height in pixels. Must be 224.
| integer = 224
| Yes |
patch_idx | Zero-based index of the tile within the slide.
| integer ≥ 0
| Yes |
tissue_ratio | Fraction of the tile area containing tissue (0.0–1.0)
| float [0.0, 1.0]
| No |
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