Sold by: CryoCloud
Deployed on AWS
CryoCloud is a cloud platform for cryo-EM, cryo-ET and X-ray crystallography data analysis. Upload data from the microscope, process it with CryoCloud's own and open-source algorithms in the cloud, and manage datasets, projects and team access in one place.
Overview
CryoCloud runs the complete structure determination workflow in your browser, from data upload and preprocessing to refinement, model building and reporting. Jobs start on cloud GPUs when they are submitted, so there is no queue and no hardware to install or maintain.
Get Started Quickly
CryoCloud offers a 30-day free trial so your team can evaluate the full platform before committing. Upload your data, run real workflows on cloud GPUs, and see results firsthand - all with no upfront commitment.
Processing That Delivers Faster Results at Lower Cost
- CryoCloud algorithms: CCMotionCorr motion correction, CTF estimation, the CryoCloud Picker, automated class selection, interactive masking and selection, model-map quality and PDF reports.
- Optimized software: CryoCloud's algorithms and the compute settings of every job are optimized for speed, so results arrive faster and cost less.
- Open-source tools are included as well: RELION (motion correction, CTF estimation, picking, extraction, 2D and 3D classification, refinement, polishing, multibody refinement, post-processing, local resolution and tomography), Topaz, CryoDRGN, DynaMight, DeepEMhancer, EMReady, LocScale, CryoSieve, ModelAngelo, Servalcat, MolProbity, AlphaFold, ColabFold and PyTom template matching.
- X-ray data processing and refinement with Global Phasing's PipeDream, available as the CrystalCloud add-on.
Automation That Keeps Your Pipeline Moving
- Workflows chain jobs into a pipeline. With automatic import enabled, a default workflow starts as soon as new data arrives.
Flexible Data Management
- Upload through the browser, or with per-dataset S3 credentials from the AWS CLI, rclone or a facility pipeline. Automatic import of new data from the microscope is available on request.
- Supported inputs include TIFF, EER and MRC movies, particle stacks and CryoSPARC exports.
- Each team has its own S3 bucket in the region of your deployment, billed per TB-month. Archiving a dataset or project to cold storage reduces its storage cost by 92%, and bringing it back is a one-click retrieval through the application.
Teams and Enterprise-Grade Security
- Flexible role-based access that you control: Owner, Admin, Member and Guest roles, View, Use or Manage access per resource, and a separate download permission.
- Multi-factor authentication, and SAML single sign-on with Okta, Microsoft Entra ID or Ping as an add-on.
- ISO/IEC 27001:2022 certified, data encrypted at rest and in transit with AWS KMS, and annual third-party penetration tests. Details are in the CryoCloud Trust Center at trust.cryocloud.io.
Deployment Options to Match Your Needs
- The Frequent Subscription gives access to the shared CryoCloud platform. The Private Cloud subscription provides a dedicated, single-tenant environment in the region of your choice, configured to integrate with your cloud.
The prices below cover these two configurations. For a private offer, contact hi@cryocloud.io
Highlights
- Instant GPU access with no queue times: Submit cryo-EM, cryo-ET, or X-ray crystallography jobs and get cloud GPUs immediately - no shared HPC cluster waits or hardware procurement. Run proprietary algorithms like CCMotionCorr and CryoCloud Picker alongside open-source tools including RELION, Topaz, CryoDRGN, and ModelAngelo, all from your browser.
- Fully automated processing from movies to maps: Optimized compute parameters and powerful automation eliminate manual steps. CryoCloud's algorithms and job settings are tuned for speed so results arrive faster. Cold storage archiving reduces storage costs by 92% compared to keeping data in active storage.
- ISO/IEC 27001 certified security: Each team's data is stored in its own encrypted S3 bucket with role-based access controls, MFA, and SAML SSO. Manage datasets, projects, and team permissions from a single interface with full audit trail visibility.
Details
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Delivery method
Deployed on AWS
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Pricing
Pricing is based on the duration and terms of your contract with the vendor, and additional usage. You pay upfront or in installments according to your contract terms with the vendor. This entitles you to a specified quantity of use for the contract duration. Usage-based pricing is in effect for overages or additional usage not covered in the contract. These charges are applied on top of the contract price. If you choose not to renew or replace your contract before the contract end date, access to your entitlements will expire.
Additional AWS infrastructure costs may apply. Use the AWS Pricing Calculator to estimate your infrastructure costs.
Dimension | Description | Cost/12 months |
|---|---|---|
Frequent Subscription | The frequent subscription includes access to CryoCloud SaaS platform with 3 team seats, 300 compute hours and 1,000 annual credits for additional services. | $12,000.00 |
Private Cloud | The private cloud offering includes access to single-tenant CryoCloud environment created specifically for you. The subscription includes 5 seats, 500 compute hours and 1,000 annual credits for additional services. | $60,000.00 |
Dimension | Description | Cost/unit |
|---|---|---|
Active Storage (TB/month) | Active storage | $25.00 |
Archive Storage (TB/month) | Archive storage | $2.00 |
Archive Transition | Transition of datasets and projects to and from archive storage, based on the file size | $0.01 |
Downloads (TB) | Downloads | $90.00 |
Additional services | Additional services, seats and compute hours | $0.01 |
Dimensions summary
You pick one of two subscription packages. The Frequent Subscription gives you 3 team seats, 300 compute hours, and 1,000 annual credits. The Private Cloud package gives you a single-tenant environment with 5 seats, 500 compute hours, and 1,000 annual credits. Both run on usage-based dimensions you add as needed: Active Storage and Archive Storage billed per TB per month, Archive Transition charged by file size when moving data in or out of archive, and Downloads billed per TB. Additional services cover extra seats and compute hours.
Top-of-mind questions for buyers
A compute hour is one hour of GPU processing time for your cryo-EM jobs. Both packages include a fixed allowance. If you reach your limit, you buy more through the Additional services dimension, which also covers extra seats and compute hours.
Active Storage and Archive Storage both bill per TB per month and run at the same time. Keeping data active costs more per TB, so active storage usually drives more cost. Moving data to archive via Archive Transition lowers ongoing storage charges. Downloads bill separately per TB when you pull data out.
Private Cloud gives you a single-tenant environment created specifically for you, running on your own isolated setup. The Frequent Subscription uses the shared SaaS platform. Private Cloud also includes 5 seats and 500 compute hours, versus 3 seats and 300 compute hours on the Frequent Subscription.
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Delivery details
Software as a Service (SaaS)
SaaS delivers cloud-based software applications directly to customers over the internet. You can access these applications through a subscription model. You will pay recurring monthly usage fees through your AWS bill, while AWS handles deployment and infrastructure management, ensuring scalability, reliability, and seamless integration with other AWS services.
Support
Vendor support
Getting Help with CryoCloud For support inquiries, contact the CryoCloud team via email at hi@cryocloud.io . You can also schedule a call through the CryoCloud website to discuss your requirements, plan a demo, or troubleshoot issues.
Security and Compliance CryoCloud is ISO/IEC 27001 certified. Details about security practices, data handling, and compliance controls are available at the CryoCloud Trust Center: https://trust.cryocloud.io .
Refunds and Billing For questions about billing, subscription management, or refund requests, please contact hi@cryocloud.io with your account details and a description of the issue.
AWS infrastructure support
AWS Support is a one-on-one, fast-response support channel that is staffed 24x7x365 with experienced and technical support engineers. The service helps customers of all sizes and technical abilities to successfully utilize the products and features provided by Amazon Web Services.
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