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This synthetic dataset contains 121 FHIR eICR document bundles compliant with the eCR Implementation Guide v2.1.0. Disease cases include COVID-19, Salmonella, Hep-B, and Hep-C in all 50 states plus 5 US territories. These are fictional representations of healthcare data intended for interoperability testing and solution development. Although realistic, the data are entirely fictitious and do not represent real persons or real clinical scenarios and pose no PHI/PII risk.