InterSystems IRIS for Health™ provides all the capabilities for building complex, mission-critical, data-intensive applications. It is a comprehensive platform spanning data management, interoperability, transaction processing and analytics, built to accelerate time to value.
Healthcare Interoperability
Offers extensive development tooling for healthcare interoperability standards as well as pre-built extensible data transformations between modern and legacy formats, including:
FHIR (DSTU2, STU3, R4)
HL7 V2 and HL7 V3
IHE Profiles, including XDS.b, XCA, PIX, PDQ, and MHD
CDA/C-CDA Documents
DICOM
X12
Native FHIR support
Provides the foundation to build powerful FHIR applications. The FHIR repository offers full read/write capabilities, receiving or sending FHIR resources via the FHIR RESTful API in JSON or XML formats. This allows applications built on the latest technologies to use FHIR data - new or mapped from legacy systems - for use in areas such as patient care, quality improvement or research.
Freedom of Choice
Features a multi-model architecture that allows you to use the data model that best fits each task in your application. Each data model is accessible through the language of your choice. The platform supports a variety of development languages, including a native API for Java, .NET, and Python.
Highlights
Efficiently enables applications to scale from scratch, both vertically and horizontally to cost-effectively handle any workload, volume of data, or users.
Native support for FHIR and every major healthcare messaging standard worldwide, applications can rapidly ingest, normalize, and share information.
Advanced data prep capabilities to create transformative healthcare models and optimize the effectiveness of learning solutions.
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This product is available free of charge. Free subscriptions have no end date and may be canceled any time.
Additional AWS infrastructure costs may apply. Use the AWS Pricing Calculator to estimate your infrastructure costs.
If you are an AWS Free Tier customer with a free plan, you are eligible to subscribe to this offer. You can use free credits to cover the cost of eligible AWS infrastructure. See AWS Free Tier for more details. If you created an AWS account before July 15th, 2025, and qualify for the Legacy AWS Free Tier, Amazon EC2 charges for Micro instances are free for up to 750 hours per month. See Legacy AWS Free Tier for more details.
This is a free listing, so the software itself carries no license charge across every option shown. Each dimension maps to a specific Amazon EC2 instance type, billed by the hour. You pick the instance that matches your compute, memory, or storage needs, from small shared instances to large memory- and compute-focused ones. Pricing scales with the size and class of the instance you choose, not with any software fee. Larger or specialized instances cost more per hour because of the underlying AWS hardware, while smaller instances cost less. You run the same platform on whichever instance you select.
Top-of-mind questions for buyers
What does one hourly unit map to, and am I charged when the instance is stopped?
Each unit is one running Amazon EC2 instance of the type you select, billed per hour. Software carries no charge on this free listing. Fully stopped instances stop accruing hourly charges, though AWS may still bill for attached storage while the instance is stopped.
If I need more compute or memory later, how does my cost change?
You switch to a different EC2 instance type from the list. Larger or specialized instances cost more per hour due to the underlying AWS hardware; smaller ones cost less. The software stays free either way. There is no automatic tier jump — you choose and launch the instance you want.
Does running this on a bigger instance unlock extra software features?
No. You run the same InterSystems IRIS for Health Community Edition platform on every instance type shown. The instance choice only affects compute, memory, and storage capacity plus the AWS hourly hardware cost. It does not change the software capabilities or add a license fee.
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An AMI is a virtual image that provides the information required to launch an instance. Amazon EC2 (Elastic Compute Cloud) instances are virtual servers on which you can run your applications and workloads, offering varying combinations of CPU, memory, storage, and networking resources. You can launch as many instances from as many different AMIs as you need.
After connecting to the AWS instance, note the connection information provided and change the default password with the command "iris password"
Load the InterSystems IRIS Management Portal in your browser with the provided URL, or start the InterSystems Terminal with "docker exec -it iris terminal iris"
InterSystems provides a fast path to get acquainted with our technology, development resources and support. Our Developer Community lets you engage to ask questions and share approaches and solutions. We offer comprehensive online learning courses. Organizations can find the full InterSystems IRIS documentation online, and when you need to solve unexpected issues, the Worldwide Response Center (WRC) is staffed 7/24/365 with professional engineers skilled in application development.
AWS Support is a one-on-one, fast-response support channel that is staffed 24x7x365 with experienced and technical support engineers. The service helps customers of all sizes and technical abilities to successfully utilize the products and features provided by Amazon Web Services.
I love that with InterSystems IRIS for Health, I can build an HL7 connection and then take that data to load it into an application that I view on a website hosted in an IRIS web application, all in one tool. It's really beneficial that object-oriented programming, a data persistence layer, SQL projection, and interoperability are all rolled into one product, which particularly helps with the interoperability layer. Setting it up is fairly easy provided the server is correctly configured. Our organization has helped several other organizations switch from their legacy engines to IRIS for Health.
What do you dislike about the product?
Their AI tools are getting better every day but not quite there yet.
What problems is the product solving and how is that benefiting you?
InterSystems IRIS for Health integrates object-oriented programming, data persistence, SQL, and interoperability, helping us solve interoperability issues effectively.
Program Development
Flexible, Powerful Interoperability for Healthcare Integrations
Reviewed on Aug 24, 2026
Review provided by G2
What do you like best about the product?
Its flexibility and powerful interoperability capabilities, especially for integrating different healthcare systems and data formats.
What do you dislike about the product?
The learning curve can be a bit steep, especially for new developers, and some features could be more intuitive and easier to use.
What problems is the product solving and how is that benefiting you?
It makes system integration and data exchange easier, reducing development effort and helping us deliver solutions faster.
George G.
Intuitive Management Portal That Makes Monitoring and Integration Easy
Reviewed on Aug 20, 2026
Review provided by G2
What do you like best about the product?
There isn't anything that doesn't work well. The management portal is intuitive to use and allows you to easily monitor your productions. This helps to ensure successful integration between different systems.
What do you dislike about the product?
Some of the documentation for methods is lacking in explanation of what they do, so you may have to read the underlying code. This can sometimes be quite difficult if the code uses a lot of abbreviations.
What problems is the product solving and how is that benefiting you?
It allows for rapid successful data flow between multiple Healthcare systems. This reduces the time doctors need to take to receive information, which means they can spend more time caring for their patients.
Felipeg2 G.
Revolutionizing Health Data Integration with Ease
Reviewed on May 28, 2026
Review provided by G2
What do you like best about the product?
I really appreciate the 'easy to use' aspect of InterSystems IRIS for Health. I like the ability to process and route HL7 messages efficiently. Although it's initially a bit tricky to find everything, over time all the functions and features become easier to use.
What do you dislike about the product?
Even though it's tough and robust, I think the UI could be a little more simple. Maybe to be more 'Modern' designed, and better readability. At first it's a bit difficult to understand where everything is located, but with the right time, all the functions and features it gets easier.
What problems is the product solving and how is that benefiting you?
InterSystems IRIS for Health solves major interoperability and data management problems, making these tasks less complex and time-consuming.
Alena K.
Powerful Interoperability and High Performance in a Unified, Secure Data Platform
Reviewed on Feb 12, 2026
Review provided by G2
What do you like best about the product?
What I like best about IRIS for Health is its powerful interoperability capabilities and high performance. It provides a unified data platform that simplifies integration between healthcare systems while ensuring reliability, scalability, and strong security.
What do you dislike about the product?
The platform has a steep learning curve, especially for teams new to the InterSystems ecosystem. Initial setup and configuration can require significant expertise.
What problems is the product solving and how is that benefiting you?
InterSystems IRIS for Health helps us solve interoperability challenges by seamlessly integrating data from multiple healthcare systems and formats (HL7, FHIR, etc.). As a result, we can deliver more reliable solutions faster while maintaining compliance and security standards.