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    Orpheus Biomedical Research API

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    Sold by: Wisecube AI 
    Deployed on AWS
    Introducing the Orpheus, a transformative service poised to redefine biomedical research and drug discovery. Amidst the rapidly expanding universe of biomedical data, Orpheus stands out as a beacon of innovation, offering healthcare providers, biomedical researchers, and drug developers direct access to the most relevant, literature-supported medical insights and advanced Semantic AI based discovery tools.

    Overview

    At the heart of Orpheus API is a groundbreaking foundational graph embedding model, meticulously trained on a vast unified biomedical knowledge graph. This foundational Semantic AI model captures the complex relationships and patterns within biomedical data, enabling the development of downstream AI/ML models tailored for a variety of drug discovery use cases.

    From identifying potential therapeutic targets to predicting drug interactions and optimizing lead compounds, Orpheus accelerates the path from research to clinical application with unprecedented precision and efficiency and provides the following functionality:

    • Advanced Biomedical Knowledge Base: Orpheus leverages a comprehensive billion-scale biomedical knowledge graph to conduct in-depth analyses and generate accurate predictions. This extensive dataset facilitates a deeper understanding of the intricate relationships between biomedical entities, driving the discovery of targeted and effective therapeutics.

    • Foundational Graph Embedding Model: The core of Orpheus's predictive power lies in its foundational graph embedding model that is trained on the knowledge graph. This model enables the creation of custom AI/ML models for various drug discovery processes, enhancing the accuracy and relevance of predictions.

    • Semantic Search with AI Precision: Empowered by advanced Semantic AI models, Orpheus API delivers a refined search experience, allowing users to filter results by relevance, publication date, and citation count. This feature ensures that users can quickly find the most pertinent information.

    • Literature-Supported Answers: Orpheus API provides detailed, literature-backed answers to complex medical queries. Access to hundreds of biomedical datasets ensures comprehensive and reliable information.

    • Cited References for Trustworthy Insights: Every piece of information provided by Orpheus API is supported by cited references, adding an extra layer of credibility and offering pathways for further investigation.

    Here are the kinds of datasets that we incorporate into our knowledge graph:

    DatasetDatasetDataset
    NCBI GeneNDF-RTHuman Disease Ontology
    EnsemblLIPID MAPSMonarch Disease Ontology
    UniProtMassBankVAERS Data
    InterProPDB LigandFAERS Data
    Protein Data BankEPA CompTox DashboardNIH Grants
    CIViC DBReactomeClinicalTrials.gov
    PubChemWikiPathwaysMEDLINE
    RxNormIUPHAR GuideCCTO

    Here are the out of the box AI models we also offer:

    ModeCategoryDescription
    LogSBasic physicochemical propertyThe log of aqueous solubility value
    LogD7.4Basic physicochemical propertyThe log of the n-octanol/water distribution coefficients at pH=7.4
    Caco2AbsorptionCaco-2 cell permeability
    PGPiAbsorptionThe inhibitor of P-glycoprotein
    PGPsAbsorptionThe substrate of P-glycoprotein
    HIAAbsorptionThe human intestinal absorption
    F (20%)AbsorptionThe human oral bioavailability. (20%)
    F (30%)AbsorptionThe human oral bioavailability. (30%)
    PPBDistributionThe plasma protein binding
    VDDistributionThe volume of distribution
    BBBDistributionThe blood brain barrier
    CYPIA2iMetabolismCYP 1A2-Inhibitor
    CYPIA2sMetabolismCYP 1A2-substrate
    CYP3A4iMetabolismCYP 3A4-Inhibitor
    CYP3A4sMetabolismCYP 3A4-Substrate
    CYP2C9iMetabolismCYP 2C9-Inhibitor
    CYP2C9sMetabolismCYP 2C9-Substrate
    CYP2CI9iMetabolismCYP 2C19-Inhibitor
    CYP2C19sMetabolismCYP 2C19-Substrate
    CYP2D6iMetabolismCYP 2D6-Inhibitor
    CYP2D6sMetabolismCYP 2D6-Substrate
    CLExcretionThe clearance of a drug
    T-HALFExcretionThe half-life of a drug
    hERGToxicityThe human ether-a-go-go related gene
    H-HTToxicityhuman hepatotoxicity
    AmesToxicityAmes test for mutagenicity
    DILIToxicityDrug-induced liver injury
    FDAMDDToxicitymaximum recommended daily dose
    SkinSToxicitySkin Sensitivity
    ROATToxicityRat oral acute toxicity

    Details

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    Deployed on AWS
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    Pricing

    Orpheus Biomedical Research API

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    Pricing is based on the duration and terms of your contract with the vendor, and additional usage. You pay upfront or in installments according to your contract terms with the vendor. This entitles you to a specified quantity of use for the contract duration. Usage-based pricing is in effect for overages or additional usage not covered in the contract. These charges are applied on top of the contract price. If you choose not to renew or replace your contract before the contract end date, access to your entitlements will expire.
    Additional AWS infrastructure costs may apply. Use the AWS Pricing Calculator  to estimate your infrastructure costs.

    12-month contract (1)

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    Dimension
    Description
    Cost/12 months
    Product Access
    Dimension that grants access to the product for subscribers.
    $0.00

    Additional usage costs (1)

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    The following dimensions are not included in the contract terms, which will be charged based on your usage.

    Dimension
    Description
    Cost/unit
    Per successful API request
    Charge for each successfull API request
    $0.15

    Vendor refund policy

    Refunds are not offered for this product

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    Usage information

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    Delivery details

    AWS Data Exchange (ADX)

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    Data sets (1)

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    You will receive access to the following data sets.

    Data set name
    Type
    Historical revisions
    Future revisions
    Sensitive information
    Data dictionaries
    Data samples
    orpheus_api
    Last 1 revisions
    All future revisions
    Not included
    Not included

    Resources

    Vendor resources