Sold by: Chan Zuckerberg Biohub
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Deployed on AWS
Tabula Muris Senis is a comprehensive compendium of single cell transcriptomic data from the model organism *Mus musculus* comprising more than 500,000 cells from 18 organs and tissues across the mouse lifespan. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence, changes in the activity of metabolic pathways, depletion of stem-cell populations, genomic instability and the role of inflammation as well as other changes in the organism’s immune system. Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.See: https://www.biorxiv.org/content/10.1101/661728v1
Overview
Tabula Muris Senis is a comprehensive compendium of single cell transcriptomic data from the model organism Mus musculus comprising more than 500,000 cells from 18 organs and tissues across the mouse lifespan. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence, changes in the activity of metabolic pathways, depletion of stem-cell populations, genomic instability and the role of inflammation as well as other changes in the organism’s immune system. Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.See: https://www.biorxiv.org/content/10.1101/661728v1
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Open data resources
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- How to use
- To access these resources, reference the Amazon Resource Name (ARN) using the AWS Command Line Interface (CLI). Learn more
- Description
- https://github.com/czbiohub/tabula-muris-senis
- Resource type
- S3 bucket
- Amazon Resource Name (ARN)
- arn:aws:s3:::czb-tabula-muris-senis
- AWS region
- us-west-2
- AWS CLI access (No AWS account required)
- aws s3 ls --no-sign-request s3://czb-tabula-muris-senis/
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If you have questions about the data, you can create an Issue at https://github.com/czbiohub/tabula-muris-senis .
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How to cite
Tabula Muris Senis was accessed on DATE from https://registry.opendata.aws/tabula-muris-senis .
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Tabula Muris is a compendium of single cell transcriptomic data from the model organism Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data represent a new resource for cell biology, reveal gene expression in poorly characterized cell populations, and allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as T-lymphocytes and endothelial cells from different anatomical locations. Two distinct technical approaches were used for most organs: one approach, microfluidic droplet-based 3’-end counting, enabled the survey of thousands of cells at relatively low coverage, while the other, FACS-based full length transcript analysis, enabled characterization of cell types with high sensitivity and coverage. The cumulative data provide the foundation for an atlas of transcriptomic cell biology. See: https://www.nature.com/articles/s41586-018-0590-4
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