Sold by: Chan Zuckerberg Biohub
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Deployed on AWS
Tabula Muris is a compendium of single cell transcriptomic data from the model organism *Mus musculus* comprising more than 100,000 cells from 20 organs and tissues. These data represent a new resource for cell biology, reveal gene expression in poorly characterized cell populations, and allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as T-lymphocytes and endothelial cells from different anatomical locations. Two distinct technical approaches were used for most organs: one approach, microfluidic droplet-based 3’-end counting, enabled the survey of thousands of cells at relatively low coverage, while the other, FACS-based full length transcript analysis, enabled characterization of cell types with high sensitivity and coverage. The cumulative data provide the foundation for an atlas of transcriptomic cell biology. See: https://www.nature.com/articles/s41586-018-0590-4
Overview
Tabula Muris is a compendium of single cell transcriptomic data from the model organism Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data represent a new resource for cell biology, reveal gene expression in poorly characterized cell populations, and allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as T-lymphocytes and endothelial cells from different anatomical locations. Two distinct technical approaches were used for most organs: one approach, microfluidic droplet-based 3’-end counting, enabled the survey of thousands of cells at relatively low coverage, while the other, FACS-based full length transcript analysis, enabled characterization of cell types with high sensitivity and coverage. The cumulative data provide the foundation for an atlas of transcriptomic cell biology. See: https://www.nature.com/articles/s41586-018-0590-4
Features and programs
Open Data Sponsorship Program
This dataset is part of the Open Data Sponsorship Program, an AWS program that covers the cost of storage for publicly available high-value cloud-optimized datasets.
Pricing
This is a publicly available data set. No subscription is required.
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Open data resources
Available with or without an AWS account.
- How to use
- To access these resources, reference the Amazon Resource Name (ARN) using the AWS Command Line Interface (CLI). Learn more
- Description
- https://github.com/czbiohub/tabula-muris
- Resource type
- S3 bucket
- Amazon Resource Name (ARN)
- arn:aws:s3:::czb-tabula-muris
- AWS region
- us-east-1
- AWS CLI access (No AWS account required)
- aws s3 ls --no-sign-request s3://czb-tabula-muris/
Resources
Vendor resources
Support
Contact
If you have questions about the data, you can create an Issue at https://github.com/czbiohub/tabula-muris .
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How to cite
Tabula Muris was accessed on DATE from https://registry.opendata.aws/tabula-muris .
Similar products
Tabula Muris Senis is a comprehensive compendium of single cell transcriptomic data from the model organism Mus musculus comprising more than 500,000 cells from 18 organs and tissues across the mouse lifespan. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence, changes in the activity of metabolic pathways, depletion of stem-cell populations, genomic instability and the role of inflammation as well as other changes in the organism’s immune system. Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.See: https://www.biorxiv.org/content/10.1101/661728v1
Tabula Sapiens is a benchmark, first-draft human cell atlas of over 1.1M cells from 28 organs of 24 normal human subjects.
This work is the product of the Tabula Sapiens Consortium.
Taking the organs from the same individual controls for genetic background, age, environment, and epigenetic effects,
and allows detailed analysis and comparison of cell types that are shared between tissues.
Our work creates a detailed portrait of cell types as well as their distribution and variation in gene expression
across tissues and within the endothelial, epithelial, stromal and immune compartments.
We have built directly on our unique skills, experience, and data infrastructure from Tabula Muris and Tabula Muris Senis
to create a high-quality human reference dataset and portal at a 10-fold larger scale from these prior efforts.
A critical factor in the Tabula projects is our large collaborative network of PIs with deep expertise at preparation of diverse organs,
enabling all organs fro[...]
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