InterSystems OMOP creates a seamless process where real-world data extraction, transformation, and loading from diverse EHRs into a managed OMOP repository becomes a catalyst for innovation and collaboration with your research partners.
InterSystems®, a creative data technology provider dedicated to helping customers solve their most critical scalability, interoperability, and speed problems, offers its market leading InterSystems OMOP service through the AWS Cloud Marketplace.
InterSystems OMOP offers a light-weight, cloud-based data pipeline and management solution combining the standard Fast Healthcare Interoperability Resources (FHIR) of EHRs with InterSystems out-of-the-box transformation to the CDM and a Software as a Service OMOP repository. With this data, you can also take advantage of the Observational Health Data Sciences and Informatics (OHDSI) community and tools to further enhance your research agenda.
Built on InterSystems IRIS for Health, InterSystems OMOP supports large-scale clinical research and patient data management with:
Efficient, Scalable Access to EHR Data: InterSystems OMOP uses the standard Bulk FHIR capabilities of your EHR(s) to update your OMOP repository with newly eligible patient records as often as nightly.
Rapid deployment for OHDSI environments: Spin up an OMOP repository and leverage the OHDSI tools, all built on InterSystems IRIS for Health, delivered in minutes in an AWS cloud environment.
Timely Data for Trial Recruitment: Frequent data updates allow clinicians and researchers to identify and recruit potential trial participants more rapidly. Reaching out to candidates immediately after care may increase their willingness to participate.
Out-of-the-Box EHR to Research Transformation: The no-code data pipeline provides standard mappings from FHIR to the OMOP CDM to transform EHR data into research-grade information and lower your ETL maintenance costs.
Continuous Data Quality Monitoring: Data quality dashboards and summary metrics ensure that problems with data quality can be identified and corrected at the source in a timely manner.
Key features include:
Automatically convert and refresh EHR data into OMOP daily, without the need for complex ETL development.
Utilize the widely adopted Bulk FHIR standard by EHR vendors.
Quickly deploy an OMOP environment with capacity based subscription pricing.
Ensure security and regulatory compliance by leveraging cloud vendor best practices.
Utilize a data quality dashboard before data transformation to detect and monitor data quality.
Enable incremental data refresh for only those patients with new data.
Out-of-the-box availability of common terminology mapping to OMOP ontology with support for local terminology mapping.
Common FHIR resources are mapped to OMOP out of the box.
Integrate IRIS as a new OMOP database option for OHDSI tools as well as sending data to existing OMOP repository.
Option to support advanced patient privacy protection.
The pricing shown is a representative pricing for a typical study configuration. Actual contract pricing is available via private offering.
Highlights
Automated FHIR to OMOP data conversion and daily refresh in secure ephemeral data enclave for research
Built in FHIR data quality checks and reports prior to OMOP transformation
AWS Marketplace now accepts line of credit payments through the PNC Vendor Finance program. This program is available to select AWS customers in the US, excluding NV, NC, ND, TN, & VT.
Pricing is based on the duration and terms of your contract with the vendor. This entitles you to a specified quantity of use for the contract duration. If you choose not to renew or replace your contract before it ends, access to these entitlements will expire.
Additional AWS infrastructure costs may apply. Use the AWS Pricing Calculator to estimate your infrastructure costs.
You buy InterSystems OMOP through a single contract dimension billed by units. The listed price reflects a 100,000-patient study, giving you a reference point for a typical research workload. Pricing scales with the size of your patient study rather than a fixed license. Because this is a capacity-based subscription, you match your commitment to the volume of patient data you plan to process. For a quote tuned to your actual study size, you work with InterSystems through a private offer, which sets the final contract terms and pricing.
Top-of-mind questions for buyers
What does one billing unit represent in this contract?
Units reflect the size of your patient study. The listed price maps to a 100,000-patient study, so units scale with how many patient records flow through the pipeline into your OMOP repository. This is a capacity-based subscription, meaning you commit to a data volume rather than a fixed seat or server count.
What is included in the contract beyond the data pipeline itself?
The contract covers a Software-as-a-Service OMOP repository with all infrastructure and software for operation. You get onboarding from a managed services team, access to the cloud portal to manage and monitor deployments, client libraries, security and data protection, and 24/7 support with real-time monitoring.
Does my cost change if I run more than one deployment?
You can create multiple deployments that are sized, managed, and accessed independently. Because pricing is capacity-based and tied to patient study size, your commitment reflects the total data volume you process across deployments rather than a flat per-deployment charge. Contact InterSystems through a private offer for terms matched to your setup.
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InterSystems provides a fast path to get acquainted with our technology, development resources and support. Our Developer Community lets you engage to ask questions and share approaches and solutions. We offer comprehensive online learning courses. Organizations can find the full InterSystems IRIS documentation online, and can rely on enterprise-level support through the iService portal, backed by a 7/24/365 response center.
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InterSystems Health Connect™ Cloud is a fully managed, enterprise-grade Interoperability service. InterSystems will securely manage protected health data (PHI) on AWS, making it easy to develop innovative healthcare applications using standards-based interoperability.
Powerful All-in-One platform, worth the learning curve
Reviewed on Sep 01, 2026
Review provided by G2
What do you like best about the product?
The things I liked the most are the performance, having the multidimensional engine is really fast to read and write even with high data volume and it gets really impressive when compared with relational databases. Also, I'd like to say that it is really multimodel, so you are able to access the same data with SQL, as an object, or using the Globals. For the last thing, the interoperability module is very mature and there's a lot of features ready-made.
What do you dislike about the product?
There are some things about IRIS that bother me a little bit, the small community, when you compare it with other technologies, is very niche. I asked about IRIS to a lot of people and they don't know what it is. Because of that, it is harder to solve very specific problems, sometimes you will have only the answer at old forums. The job market is very limited, it is hard to find someone who has experience with IRIS, and to hire someone and train them takes time. The licensing cost is not very accessible, so only big companies can afford it.
What problems is the product solving and how is that benefiting you?
The built-in interoperability engine has been very important to reduce development time on integration projects. I can use pre-built adapters and visual pipelines to route and transform messages. What took me weeks now takes days.
Computer Software
High performance, seamless integration, and excellent support
Reviewed on Aug 21, 2026
Review provided by G2
What do you like best about the product?
I admire the response speed, especially when dealing with huge volumes of data; it is perfect for integrations and offers excellent assistance and support. Yes, since I started, I’ve more than doubled my profits using InterSystems IRIS!!
What do you dislike about the product?
Migrating from modern systems to learn ObjectScript is a bit of a hassle and requires more time.
What problems is the product solving and how is that benefiting you?
IRIS has a massive focus on the healthcare sector and comes with built-in support for global protocols such as HL7 and FHIR
Aziz C.
Iris’ Data Persistence Is a Game-Changer
Reviewed on Aug 20, 2026
Review provided by G2
What do you like best about the product?
I think IRIS is a really good product overall, even though it can feel a bit complex at times. What I appreciate the most is the data persistence, which has been especially valuable for my use case. It gives me confidence that the data I need will be there when I need it.
The IRIS portal interface is intuitive up to a point and generally easy to navigate. It took some time to get familiar with certain parts of the platform, but once you understand how things are organized, it becomes much easier to work with.
I also really like how straightforward it is to work with integrations. Setting them up and managing them has been a good experience so far, and I haven't had many issues in that area. The overall performance is another strong point for me. The platform feels reliable and performs well during day to day use.
Overall, I think IRIS is a solid product with a good combination of functionality, performance, and reliability. There is definitely a learning curve in some areas, but once you get used to the platform, it becomes much easier to use and provides a lot of value.
What do you dislike about the product?
One of the main challenges for me has been getting answers to questions or finding solutions when something goes wrong. Since IRIS isn’t as widely known or used as some other technologies, it can sometimes be difficult to find relevant information, examples, or people who have faced the same issue before.
The licensing cost can also be a concern, especially for companies that are considering adopting the technology or expanding its use. It can make it harder to justify the investment compared to more widely used alternatives.
That said, I think InterSystems’ AI could make a big difference here. Having AI support built around the platform could make it easier to find answers, understand how things work, and solve problems without having to rely as much on external resources. I think this could significantly reduce the learning curve and make IRIS more approachable for new users.
What problems is the product solving and how is that benefiting you?
Please improve the documentation. The current version can be quite confusing and sometimes makes it difficult to understand how certain features work or how to solve a specific problem. It would be really helpful to have clearer explanations, more practical examples, and better organized information. Improving the documentation would make it much easier for new users to get started and for existing users to find answers when they need them.
Benjamin Z.
Robust and High-Performance ERP Platform
Reviewed on Feb 01, 2026
Review provided by G2
What do you like best about the product?
I like that InterSystems IRIS is particularly well-suited for ERP applications requiring reliability, performance, and data consistency. The platform's flexibility facilitates integrations, especially with nginx as a web server and HAProxy as a reverse proxy. Additionally, the initial setup is easy, and the product's security hardening is facilitated by the online documentation.
What do you dislike about the product?
The areas for improvement mainly involve integrations with other platforms.
What problems is the product solving and how is that benefiting you?
We use InterSystems IRIS to manage complex transactional data, develop robust business logic, and expose high-performance APIs, while being well-suited for ERP applications requiring reliability, performance, and data consistency.
Stav B.
Essential Platform with Stellar Support, Steep Learning Curve
Reviewed on Jan 29, 2026
Review provided by G2
What do you like best about the product?
I really appreciate the Worldwide Response Center (WRC) provided by InterSystems IRIS. Their support team is incredibly responsive and knowledgeable, answering every question with great expertise. It feels like having an extension of our own team. The WRC is a game changer, especially in sectors like finance and automotive where downtime isn't an option. I value that we can set the priority of the ticket and, in crisis situations, they provide immediate access to engineers who truly solve the problem.
What do you dislike about the product?
The learning curve can be steep, especially for newer features or complex cloud configurations. While the documentation is extensive, it can sometimes be difficult to find specific examples for advanced scenarios.
What problems is the product solving and how is that benefiting you?
InterSystems IRIS provides high performance and stability, ensuring data consistency and speed for real-time transaction processing. It eliminates downtime, making our ERP robust and responsive.