InterSystems is launching a fully managed, enterprise-grade FHIR® service, hosted on AWS and available in the US. InterSystems will securely manage protected health data (PHI) on AWS, making it easy to develop innovative healthcare applications using FHIR.
The InterSystems FHIR® Server provides high-performance FHIR storage, searching, and analytics capabilities for healthcare applications. Whether you're creating clinical patient apps with SMART on FHIR, or developing backend services handling bulk data, you can bring them to market faster using the InterSystems FHIR Server, with absolute confidence in the availability, speed, and reliability of your data store.
Evolving market needs have created new opportunities for innovation in healthcare sectors globally. Patient access and engagement, clinical decision support, social determinants of health, population health and research have all benefitted from FHIR and are being used daily to drive better outcomes. Regulatory incentives have provided greater API support and development frameworks to integrate with major health data producers, such as EHRs, QHINs, and health applications. The InterSystems FHIR Server provides the data and integration capabilities needed to connect directly to these providers, build cutting-edge solutions, and start innovating within minutes.
Highlights
Easy-to-deploy production-grade FHIR servers available in minutes with built-in support for STU3, R4, and R5 versions, national core implementations (US, UK, FR, IL, AU, etc.), Da Vinci, CARIN BB, CareConnect, and many more. Includes extensive SMART on FHIR capabilities, OAuth 2.0 integration (Auth0, Google Identity, Okta, Ping, Azure AD), and SMART scope validation for use in clinical apps, payer platforms, and digital health solutions.
Advanced search and Bulk FHIR Exchange to rapidly import and query data from external FHIR Servers, EHRs, and healthcare platforms. Provides built-in resource operations, fast and comprehensive search APIs, and referential integrity checks to ensure scalable ingestion and querying of high-quality clinical data.
Integrated Analytics and the FHIR SQL Builder enable real-time intelligence, cohort building, and population health dashboards using industry standard tools, without any data duplication. Securely query your FHIR Server over xDBC with PowerBI, Tableau, or client applications.
AWS Marketplace now accepts line of credit payments through the PNC Vendor Finance program. This program is available to select AWS customers in the US, excluding NV, NC, ND, TN, & VT.
You pay based on what you use, with three separate metrics billed by the hour. The first tracks compute, charging per vCPU deployed each hour. The second tracks storage, charging for each 10 GB chunk allocated per hour. The third is an add-on: if you turn on advanced features such as the FHIR SQL Builder, you pay one unit per hour while they run. These metrics combine, so your total scales with the compute size, storage volume, and whether advanced features are enabled.
Top-of-mind questions for buyers
What does one vCPU deployed per hour actually measure for billing?
You are charged per virtual CPU allocated to your running FHIR Server each hour. The FHIR Server runs on a data platform hosted in the cloud. Charges accrue while the compute is deployed, so a larger vCPU allocation raises the hourly compute charge.
What do I get when I enable the advanced features unit, such as the FHIR SQL Builder?
The advanced features unit adds one charge per hour while enabled. The FHIR SQL Builder lets you run analytics directly on the FHIR Server using SQL and standard business intelligence tools, without converting or duplicating data. If you leave these features off, this unit does not apply.
Which metric drives most of my bill, and do they all charge at once?
All three metrics bill at the same time and add together on one invoice. Compute (vCPU) usually dominates for busy workloads. Storage grows in 10 GB chunks and rises as your stored FHIR data increases. The advanced features unit adds a steady hourly charge only while enabled.
Tell us how we can improve this page, or report an issue with this product.
Give us feedbackReport a problem with this product or seller
Legal
Vendor terms and conditions
Upon subscribing to this product, you must acknowledge and agree to the terms and conditions outlined in the vendor's End User License Agreement (EULA).
Content disclaimer
Vendors are responsible for their product descriptions and other product content. AWS does not warrant that vendors' product descriptions or other product content are accurate, complete, reliable, current, or error-free.
SaaS delivers cloud-based software applications directly to customers over the internet. You can access these applications through a subscription model. You will pay recurring monthly usage fees through your AWS bill, while AWS handles deployment and infrastructure management, ensuring scalability, reliability, and seamless integration with other AWS services.
InterSystems provides a fast path to get acquainted with our technology, development resources and support. Our Developer Community lets you engage to ask questions and share approaches and solutions. We offer comprehensive online learning courses. Organizations can find the full InterSystems IRIS documentation online, and when you need to solve unexpected issues, the Worldwide Response Center (WRC) is staffed 7/24/365 with professional engineers skilled in application development support@intersystems.com
AWS infrastructure support
AWS Support is a one-on-one, fast-response support channel that is staffed 24x7x365 with experienced and technical support engineers. The service helps customers of all sizes and technical abilities to successfully utilize the products and features provided by Amazon Web Services.
InterSystems Health Connect™ Cloud is a fully managed, enterprise-grade Interoperability service. InterSystems will securely manage protected health data (PHI) on AWS, making it easy to develop innovative healthcare applications using standards-based interoperability.
I like that iris keeps all in one place like data storage integration and API's.
The security is built in and being able to use object script and SQL makes development more flexible and it performs very well on heavy load especially when dealing with healthcare data.
What do you dislike about the product?
The learning curve is a bit difficult because it has a lot of features and can be difficult for a beginner to understand without a senior or trainer. overall, it takes time to get comfortable
What problems is the product solving and how is that benefiting you?
It has all in one place so no need to have different tools for database, integration and analytics
Djonata N.
Straightforward Data Manipulation with Elegant SQL Joins
Reviewed on Oct 06, 2026
Review provided by G2
What do you like best about the product?
What I like best is how straightforward data manipulation is. I love using simple commands to open a database register, like %Open, or accessing records by index using IdxUserNameOpen. On top of that, writing implicit joins using the -> operator in SQL queries is hands down the most elegant way to query data.
What do you dislike about the product?
The license model is a bit complicated. It's not always simple to understand or accurately measure how licensing is consumed in real-world scenarios.
What problems is the product solving and how is that benefiting you?
The biggest benefit I found in IRIS is that I don't need multiple databases anymore—one for caching, another for structured data, and a separate one for columnar values. Everything is handled in one single place.
Paulo Z.
Impeccable Fluency, Necessary Modernization
Reviewed on Sep 26, 2026
Review provided by G2
What do you like best about the product?
I really like the fluency of InterSystems IRIS and its unique global features. It's the first time I've used a technology with this capability, and I find it incredibly interesting. I enjoy how globals can be modified into tables, which makes them versatile and fascinating to work with.
What do you dislike about the product?
I work with something deprecated called Studio, and I find it quite complicated to use because it doesn't have many features. This bothers me a lot. I hope to use newer technologies in the future, like Visual Studio Code, which would probably provide me with a better experience.
What problems is the product solving and how is that benefiting you?
InterSystems IRIS allows me to process data very quickly and with precision, handling large datasets effectively.
Eric B.
Powerful All-in-One platform, worth the learning curve
Reviewed on Sep 01, 2026
Review provided by G2
What do you like best about the product?
The things I liked the most are the performance, having the multidimensional engine is really fast to read and write even with high data volume and it gets really impressive when compared with relational databases. Also, I'd like to say that it is really multimodel, so you are able to access the same data with SQL, as an object, or using the Globals. For the last thing, the interoperability module is very mature and there's a lot of features ready-made.
What do you dislike about the product?
There are some things about IRIS that bother me a little bit, the small community, when you compare it with other technologies, is very niche. I asked about IRIS to a lot of people and they don't know what it is. Because of that, it is harder to solve very specific problems, sometimes you will have only the answer at old forums. The job market is very limited, it is hard to find someone who has experience with IRIS, and to hire someone and train them takes time. The licensing cost is not very accessible, so only big companies can afford it.
What problems is the product solving and how is that benefiting you?
The built-in interoperability engine has been very important to reduce development time on integration projects. I can use pre-built adapters and visual pipelines to route and transform messages. What took me weeks now takes days.
Computer Software
High performance, seamless integration, and excellent support
Reviewed on Aug 21, 2026
Review provided by G2
What do you like best about the product?
I admire the response speed, especially when dealing with huge volumes of data; it is perfect for integrations and offers excellent assistance and support. Yes, since I started, I’ve more than doubled my profits using InterSystems IRIS!!
What do you dislike about the product?
Migrating from modern systems to learn ObjectScript is a bit of a hassle and requires more time.
What problems is the product solving and how is that benefiting you?
IRIS has a massive focus on the healthcare sector and comes with built-in support for global protocols such as HL7 and FHIR