Sold by: Allen Institute
Open data
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Deployed on AWS
The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) consortium strives to gain a deep molecular and cellular understanding of the early pathogenesis of Alzheimer's disease and is funded by the National Institutes on Aging (NIA U19AG060909). The SEA-AD datasets available here comprise single cell profiling (transcriptomics and epigenomics) and quantitative neuropathology. To explore gene expression and chromatin accessibility information, the single-cell profiling data includes: snRNAseq and snATAC-seq data from the SEA-AD donor cohort (aged brains which span the spectrum of Alzheimer's Disease pathology) and neurotypical reference brains. To explore key pathological proteins and cell types of interest to Alzheimer's disease, the neuropathology data includes: full resolution brightfield images, images processed and segmented in HALO image analysis software, image annotations, and quantification summary files for the relevant stains including Abeta (6E10), IBA1, a-Synuclein, G[...]
Overview
The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) consortium strives to gain a deep molecular and cellular understanding of the early pathogenesis of Alzheimer's disease and is funded by the National Institutes on Aging (NIA U19AG060909). The SEA-AD datasets available here comprise single cell profiling (transcriptomics and epigenomics) and quantitative neuropathology. To explore gene expression and chromatin accessibility information, the single-cell profiling data includes: snRNAseq and snATAC-seq data from the SEA-AD donor cohort (aged brains which span the spectrum of Alzheimer's Disease pathology) and neurotypical reference brains. To explore key pathological proteins and cell types of interest to Alzheimer's disease, the neuropathology data includes: full resolution brightfield images, images processed and segmented in HALO image analysis software, image annotations, and quantification summary files for the relevant stains including Abeta (6E10), IBA1, a-Synuclein, GFAP, H&E-LFB, NeuN, pTau(AT8), and pTDP43.
Features and programs
Open Data Sponsorship Program
This dataset is part of the Open Data Sponsorship Program, an AWS program that covers the cost of storage for publicly available high-value cloud-optimized datasets.
Pricing
This is a publicly available data set. No subscription is required.
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Delivery details
AWS Data Exchange (ADX)
AWS Data Exchange is a service that helps AWS easily share and manage data entitlements from other organizations at scale.
Open data resources
Available with or without an AWS account.
- How to use
- To access these resources, reference the Amazon Resource Name (ARN) using the AWS Command Line Interface (CLI). Learn more
- Description
- Single cell profiling (transcriptomics and epigenomics) data files in a public bucket
- Resource type
- S3 bucket
- Amazon Resource Name (ARN)
- arn:aws:s3:::sea-ad-single-cell-profiling
- AWS region
- us-west-2
- AWS CLI access (No AWS account required)
- aws s3 ls --no-sign-request s3://sea-ad-single-cell-profiling/
- Description
- Update notifications for s3://sea-ad-single-cell-profiling. Users can subscribe to this SNS topic with [AWS Lambda](https://aws.amazon.com/lambda/) or [AWS Simple Queue Service](https://aws.amazon.com/sqs/).
- Resource type
- SNS topic
- Amazon Resource Name (ARN)
- arn:aws:sns:us-west-2:208217671510:sea-ad-single-cell-profiling-object_created
- AWS region
- us-west-2
- Description
- Quantitative neuropathology (full resolution images, processed images, and quantifications) in a public bucket
- Resource type
- S3 bucket
- Amazon Resource Name (ARN)
- arn:aws:s3:::sea-ad-quantitative-neuropathology
- AWS region
- us-west-2
- AWS CLI access (No AWS account required)
- aws s3 ls --no-sign-request s3://sea-ad-quantitative-neuropathology/
- Description
- Update notifications for s3://sea-ad-quantitative-neuropathology. Users can subscribe to this SNS topic with [AWS Lambda](https://aws.amazon.com/lambda/) or [AWS Simple Queue Service](https://aws.amazon.com/sqs/).
- Resource type
- SNS topic
- Amazon Resource Name (ARN)
- arn:aws:sns:us-west-2:208217671510:sea-ad-quantitative-neuropathology-object_created
- AWS region
- us-west-2
- Description
- Spatial transcriptomics data files in a public bucket
- Resource type
- S3 bucket
- Amazon Resource Name (ARN)
- arn:aws:s3:::sea-ad-spatial-transcriptomics
- AWS region
- us-west-2
- AWS CLI access (No AWS account required)
- aws s3 ls --no-sign-request s3://sea-ad-spatial-transcriptomics/
- Description
- Update notifications for s3://sea-ad-spatial-transcriptomics. Users can subscribe to this SNS topic with [AWS Lambda](https://aws.amazon.com/lambda/) or [AWS Simple Queue Service](https://aws.amazon.com/sqs/).
- Resource type
- SNS topic
- Amazon Resource Name (ARN)
- arn:aws:sns:us-west-2:208217671510:sea-ad-spatial-transcriptomics-object_created
- AWS region
- us-west-2
Resources
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How to cite
Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) was accessed on DATE from https://registry.opendata.aws/allen-sea-ad-atlas .
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