Gabriella Miller Kids First Pediatric Research Program (Kids First)
Gabriella Miller Kids First Pediatric Research Program (Kids First)
This product is part of the AWS Open Data Sponsorship Program and contains data sets that are publicly available for anyone to access and use. No subscription is required. Unless specifically stated in the applicable data set documentation, data sets available through the AWS Open Data Sponsorship Program are not provided and maintained by AWS.
Description
The NIH Common Fund's Gabriella Miller Kids First Pediatric Research Program’s (“Kids First”) vision is to “alleviate suffering from childhood cancer and structural birth defects by fostering collaborative research to uncover the etiology of these diseases and by supporting data sharing within the pediatric research community.” The program continues to generate and share whole genome sequence data from thousands of children affected by these conditions, ranging from rare pediatric cancers, such as osteosarcoma, to more prevalent diagnoses, such as congenital heart defects. In 2018, Kids First launched the Gabriella Miller Kids First Data Resource Center, charged with building a large-scale data platform supporting clinical and genetic data from these patients and their families in order to accelerate discovery and ultimately clinical impact. Researchers can search, access, aggregate, and analyze these data through the Kids First Data Resource Portal. Additionally, by using cloud-based individual workspaces in CAVATICA, a data analysis and sharing computation platform, researchers can cross-analyze Kids First data with data from other efforts, such as NCI’s TARGET program and consortia-based datasets like the Children’s Brain Tumor Tissue Consortium (CBTTC). Kids First is made available on AWS via the NIH STRIDES Initiative.
License
NIH Genomic Data Sharing Policy: https://gdc.cancer.gov/access-data/data-access-policies
Documentation
How to cite
Gabriella Miller Kids First Pediatric Research Program (Kids First) was accessed on DATE from https://registry.opendata.aws/kids-first .
Update frequency
Data is updated on a rolling basis by the KFDRC to make data available as
rapidly as possible under the NIH Genomic Data Sharing Policy.
Support information
Managed by: The Gabriella Miller Kids First Data Resource Center at the Children's Hospital of Philadelphia
Contact: support@kidsfirstdrc.org
General AWS Data Exchange support
Resources on AWS
Description
Kids First: Pediatric Research Project on the Genomic Analysis of Congenital Diaphragmatic Hernia
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-46sk55a3AWS Region
us-east-1Description
National Heart, Lung, and Blood Institute (NHLBI) Bench to Bassinet Program: The Gabriella Miller Kids First Pediatric Research Program of the Pediatric Cardiac Genetics Consortium (PCGC)
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-preasa7sAWS Region
us-east-1Description
Gabriella Miller Kids First (GMKF) Pediatric Research Program in Susceptibility to Ewing Sarcoma Based on Germline Risk and Familial History of Cancer
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-ygva0e1cAWS Region
us-east-1Description
Kids First: Genomic Studies of Orofacial Cleft Birth Defects
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-9pyzahheAWS Region
us-east-1Description
GMKF: Kids First Pediatric Research Program on Congenital Cranial Dysinnervation Disorders and Related Birth Defects
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-dztb5hrrAWS Region
us-east-1Description
Kids First: Pediatric Research Project on Adolescent Idiopathic Scoliosis
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-rm8afw0rAWS Region
us-east-1Description
Disorders/Differences of Sex Development (DSD) Study Performed at UCLA in Collaboration with the DSD-Translational Research Network (DSD-TRN), with the Support of the Gabriella Miller Kids First Pediatric Research Program
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-6fpyjqbrAWS Region
us-east-1Description
Kids First: Genomics of Orofacial Cleft Birth Defects in Latin American Families
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-r0eprsgsAWS Region
us-east-1Description
Discovering the Genetic Basis of Human Neuroblastoma: A Gabriella Miller Kids First Pediatric Research Program (Kids First) Project
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-dypmehhfAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Enchondromatoses and Related Malignant Tumors
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-7nq9151jAWS Region
us-east-1Description
Kids First Pediatric Research Study in Familial Predisposition to Hematopoietic Malignancies (SJFAMILY-HM)
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-vttshwv4AWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Whole Genome Sequencing of African and Asian Orofacial Clefts Case-Parent Triads
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-dk0krwk8AWS Region
us-east-1Description
Kids First: Whole Genome Sequencing of Nonsyndromic Craniosynostosis
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-p445achvAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Germline and Somatic Variants in Myeloid Malignancies in Children
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-pet7q6f2AWS Region
us-east-1Description
Kids First and INCLUDE: Down Syndrome, Heart Defects, and Acute Lymphoblastic Leukemia
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-z6mwd3h0AWS Region
us-east-1Description
Kids First: Genetics of Kidney and Urinary Tract Malformations
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-nmvv8a1yAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Genetics at the Intersection of Childhood Cancer and Birth Defects
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-jws3v24dAWS Region
us-east-1Description
Pediatric Brain Tumor Atlas: PNOC
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-m3dbxd12AWS Region
us-east-1Description
Kids First Pediatric Research Study in Familial Predisposition to Hematopoietic Malignancies (SJFAMILY-HM)
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-w0v965xzAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program: An Integrated Clinical and Genomic Analysis of Treatment Failure in Pediatric Osteosarcoma
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-zxjffmefAWS Region
us-east-1Description
Chordoma Foundation Dataset
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-7spqtt8mAWS Region
us-east-1Controlled access
Description
Clinical Sequencing Exploratory Research Consortium: Incorporation of Genomic Sequencing into Pediatric Cancer Care
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-zfgdg5ysAWS Region
us-east-1Description
Kids First: Genomic Analysis of Esophageal Atresia and Tracheoesophageal Fistulas and Associated Congenital Anomalies
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-0tyvy1twAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Bladder Exstrophy, Epispadias, Complex (BEEC)
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-z0d9n23xAWS Region
us-east-1Description
Children's Brain Tumor Network
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-bhjxbdqkAWS Region
us-east-1Description
Kids First: Structural Defects of The Neural Tube
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-15a2mqq9AWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Project in Cornelia de Lange Syndrome, Related Diagnosis and Structural Birth Defects
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-2cekq05vAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Pediatric T-cell Acute Lymphoblastic Leukemia
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-aq9kvn5pAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Program in Craniofacial Microsomia
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-b8x3c1mxAWS Region
us-east-1Description
Gabriella Miller Kids First Pediatric Research Project in Microtia in Hispanic Populations
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-dz4gpqx6AWS Region
us-east-1Description
The Collaboration to Assess Risk and Identify LoNG-term outcomes for Children with COVID (CARING for Children with COVID) - NICHD-2019-POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children per Standard of Care
Resource type
S3 Bucket
Amazon Resource Name (ARN)
arn:aws:s3:::kf-study-us-east-1-prd-sd-ffvq3t38AWS Region
us-east-1Usage examples
Publications
- Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy by Eshini Panditharatna, Lindsay B Kilburn, et al.
- Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans. by Mary C Whitman, Noriko Miyake, et al.
- Deleterious de novo variants of X-linked ZC4H2 in females cause a variable phenotype with neurogenic arthrogryposis multiplex congenita. by Suzanna G M Frints, Friederike Hennig, et al.
- Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. by Fengqi Chang, Fumin Lin, et al.
- Elucidation of de novo small insertion/deletion biology with parent-of-origin phasing. by Allison H Seiden, Felix Richter, et al.
- Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect by Sherin Shaaban, Sarah MacKinnon et al.
- Genome-wide Enrichment of De Novo Coding Mutations in Orofacial Cleft Trios. by Madison R Bishop, Kimberly K Diaz Perez, et al.
- Genomic Analyses Implicate Noncoding De Novo Variants in Congenital Heart Disease. by Felix Richter, Sarah U Morton, et al.
- Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma. by Laura Egolf, Zalman Vaksman, et al.
- Germline microsatellite genotypes differentiate children with medulloblastoma. by Samuel Rivero-Hinojosa, Nicholas Kinney, et al.
- MACF1 Mutations Encoding Highly Conserved Zinc-Binding Residues of the GAR Domain Cause Defects in Neuronal Migration and Axon Guidance by William B Dobyns, Kimberly A Aldinger, et al.
- MAGEL2-Related Disorders: A study and case series. by Jameson Patak, James Gilfert, et al.
- Phenotype delineation of ZNF462 related syndrome. by Paul Kruszka, Tommy Hu, et al.
- The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. by Deanne M Taylor, Bruce J Aronow, et al.
- Whole genome sequencing of orofacial cleft trios from the Gabriella Miller Kids First Pediatric Research Consortium identifies a new locus on chromosome 21. by Nandita Mukhopadhyay, Madison Bishop, et al.
Tools & Applications