Managing Cisco Secure Access through the single cloud management console will not be difficult if you experience it once. This means once you have hands-on experience, you know how to operate it. In the first time, you might have a challenge because you need to understand the system. However, once you understand it, it will not be difficult anymore.
I find the zero trust approach helpful and beneficial in securing standard applications, which means you are accessing the applications directly instead of giving privilege to access the network itself. This is very beneficial in the context of security and is very effective.
Regarding the threat detection and response capabilities, because it's integrated in the cloud, users don't have to configure it to integrate with Talos. The feed that it has is already there, detecting malware and blocking it by itself from the Cisco Secure Access. The Intel is there, and we do not need to manually integrate with Talos.