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Sentieon Genomics Suite

By: Sentieon Inc. Latest Version: 201911.01

Product Overview

Sentieon ( supplies award-winning software tools for secondary analysis of NGS data.

Sentieon DNAseq and TNseq produce results identical to the Broad Institute's BWA-GATK HaplotypeCaller/MuTect/MuTect2 Best Practice Workflow by implementing the same mathematics but with more efficient computing algorithms and enterprise-strength software implementation. Furthermore, the Sentieon tools do not downsample in high-coverage regions, are able to handle arbitrary depth of coverage, and have no thread dependency, resulting in 100% consistency.

Sentieon DNAscope and TNscope build upon and improve over the mathematical models from Haplotyper/Mutect2, providing additional accuracy and supporting the use of Machine Learning models for filtering.

The Sentieon tools are enterprise-strength software tools that are inherently multi-threading and distributed-processing ready, and allow efficient processing and joint calling of extremely large cohorts. They are easily deployable, easily scalable, and easily upgradable software-only solutions running on AWS CPU instances.
Typical runtime for a single sample: DNAseq will process a 100X WES sample in 15 mins, and a 30x WGS in 3 h on a c5d.8xlarge instance.

The Sentieon AMI ships with a fully-featured trial license valid for 14 days after launch. To continue using the Sentieon tools after the trial period is completed, please contact or go to



Operating System

Linux/Unix, Amazon Linux 2017.09

Delivery Methods

  • Amazon Machine Image

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