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The Encyclopedia of DNA Elements (ENCODE) Consortium is an international collaboration of
research groups funded by the National Human Genome Research Institute (NHGRI). The goal
of ENCODE is to build a comprehensive parts list of functional elements in the human genome,
including elements that act at the protein and RNA levels, and regulatory elements that
control cells and circumstances in which a gene is active. ENCODE investigators employ a
variety of assays and methods to identify functional elements. The discovery and annotation
of gene elements is accomplished primarily by sequencing a diverse range of RNA sources,
comparative genomics, integrative bioinformatic methods, and human curation. Regulatory
elements are typically investigated through DNA hypersensitivity assays, assays of
DNA methylation, and immunoprecipitation (IP) of proteins that interact with DNA and RNA,
i.e., modified histones, transcription factors, chromatin regulators, and
RNA-binding proteins, followed[...]