About TCBG

The Theoretical and Computational Biophysics Group (TCBG), NIH Center for Macromolecular Modeling and Bioinformatics, was founded by Professor Klaus Schulten in 1989 and is located at the Beckman Institute of the University of Illinois at Urbana-Champaign (UIUC). The TCBG brings the most advanced molecular modeling, bioinformatics, and computational technologies to bear on questions of biomedical relevance. We extend, refine and deliver these technologies in response to experimental progress and emerging needs of the wide biomedical research community. We magnify the impact of our work through direct collaboration with experimental researchers, the distribution of cutting-edge and user-friendly software, and via extensive training, service, and dissemination efforts. Our technological efforts focus on the development of efficient software that facilitates the discovery process from analysis, through modeling, to visualization of the molecular apparatus in biological cells. The software supports rational drug design and is freely available (source code and binaries) to laboratories where biomolecular aggregates are discovered and measured.