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Training Machine Learning Models in Pharma and Biotech Manufacturing with Bigfinite

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By Rumi Olsen, Partner Solutions Architect at AWS

Creating and training machine learning models has become less time consuming and more cost efficient thanks to technology advancements like open source software libraries and Amazon EC2 P3 Instances, which accelerate machine learning and high-performance computing applications with powerful GPUs.

While market adoption of machine learning (ML) varies across industry segments, healthcare and life sciences have lots of opportunity to explore. Pharmaceutical and biotech industries, specifically, have low utilization of the large volumes of data they collect and store for regulatory purposes.

Bigfinite is an AWS Partner Network (APN) Standard Technology Partner that offers a number of ML solutions to enhance utilization and management of such data in a way that adheres to Good Manufacturing Practice (GMP) in the cloud.

These solutions leverage the large volume of data to create artificial intelligence (AI) and ML capabilities to solve specific problems and support life sciences manufacturing.

Bigfinite allows manufacturers to discover new ways to optimize processes, reduce manufacturing quality issues, and enhance regulatory compliance. They incorporate predictions based on machine learning and advanced analytics.

One example of an AI implementation is called Predictive Overall Equipment Effectiveness (OEE), which increases the value of traditional OEE by finding hidden relationships between the equipment’s availability.

Visualizing Relationships in the Data

Bigfinite helps manufacturers develop their own custom machine learning predictive model by providing key features that walk them through the ML processes.

After uploading the data to a cloud storage, users can implement unsupervised AI algorithms that explore the data and find patterns hidden within. This capability greatly simplifies the process of selecting appropriate data sources for training predictive models. For example, if you want to predict oxygen concentration for a batch, the platform helps answer question such as, “What data should be used to train a model to make a prediction?”

If you have a large number of attributes, a question like this would not be easy to answer. Using the built-in unsupervised AI models, however, visualizes and shows you such relationships.

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Figure 1 – Examples of Bigfinite visualizations of correlation of data attributes.

Choosing the Right Machine Learning Algorithm

Another Bigfinite feature is discovery, which helps manufacturers perform the initial data exploration that guides them to the appropriate ML algorithm they should use to train.

Machine learning practitioners spend the majority of their time exploring, preparing, integrating, and analyzing data for model training. The discovery feature helps you do that quickly and efficiently.

Figures 2 and 3 show how users can explore patterns within the data prior to training predictive AI models.

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Figure 2 – Users can create an AI model using this graphical interface.

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Figure 3 – Visual explorations of data relationships in Bigfinite.

The trained model will be used for capabilities such as Predictive OEE. Figure 4 shows a real-time visualization of a production line and predicted values—namely, Quantity to be produced and Quantity after 30 minutes.

Manufacturers can use those predictions to better understand how their equipment is performing and when to expect the production to be done. They could also use this information to plan when to service the equipment by looking at its overall performance.

In this way, manufacturers can proactively replace parts instead of letting them run until they stop. With ML models, the overall efficiency of manufacturing processes can be optimized.

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Figure 4 – A real-time visualization of a production line with Predictive OEE.

Conclusion

Bigfinite helps manufacturers enhance the utilization and management of data and leverage the benefits of AI and ML capabilities.

Bigfinite is targeted toward the pharmaceutical industry, but the same technology or method can be applied to manufacturers in any industry. Contact Bigfinite if you’d like to get more information about the platform.

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Bigfinite – APN Partner Spotlight

Bigfinite is an APN Standard Technology Partner. They offer a number of machine learning solutions to enhance utilization and management of such data in a way that adheres to Good Manufacturing Practice (GMP) in the cloud.

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